"Everyone has their own road and I think for me, having all the struggles that I've had have really helped me now,” said Giron, who will face No.22 seed Cristian Garin on Friday. “I don't take these matches for granted, I don't take these moments for granted, I think all of those experiences that I have, the tough matches that I've lost, the injuries, all of those are kind of coming into play now, and I've learned from them."
Johnson has come through two grueling five-setters to reach the third round at Roland-Garros for the fourth time, while Opelka and Giron have never tasted the second week of a Slam before. Isner, a former Wimbledon semi-finalist, has been to the round of 16 twice in Paris.
Whatever their past experience, these American men are currently all in the same state of mind.
"We've got a good group of hungry players," Giron said. "We have a lot of players in the top-100 and I think we're all hungry to prove what we can do."