US Open finalist Leylah Fernandez eased through her first two rounds and now faces Olympic champion Belinda Bencic first up on Court Philippe-Chatrier.
>> ORDER OF PLAY: Day 6 - Friday May 27
They are followed by defending champion Novak Djokovic as his quest for a third Roland-Garros title continues apace. The Serb faces Slovenian Aljaz Bedene who is looking to make the fourth round of the tournament on his 10th attempt.
French wildcard Diane Parry can once again count on the support of home fans as she comes up against former Roland-Garros finalist Sloane Stephens.
No.6 seed Carlos Alcaraz will be looking to put his dramatic second-round escape from Albert Ramos-Vinolas behind him as he closes out the action on Chatrier against Sebastian Korda, who booked his place in the third round with a win against Richard Gasquet on Wednesday.
Another escape artist from the second round, No.3 seed Alexander Zverev takes to Court Suzanne-Lenglen to face world No.75 Brandon Nakashima.
A pick of the treats across the other show courts includes the youth versus experience match-up of Coco Gauff and Kaia Kanepi on Court Suzanne-Lenglen, which is followed by world No.29 Botic van de Zandschulp as he tries to halt Rafael Nadal's bid for a 14th title here in Paris.